Detailed summary for ISC1:
Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
Excessive iron causes YCA1-dependent cell death, presumably through a pathway in which cardioliping activates the neutral sphingomyelinase ISC1, which in turn generates ceramide
- caspase dependent
- cellular component
- biological process
- molecular function
- Almeida, T., et al. (2008) Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis, Mol Biol Cell, 19, 865-876.
- Madeo, F., et al. (2009) Caspase-dependent and caspase-independent cell death pathways in yeast, Biochem Biophys Res Commun, 382, 227-231.
- Carmona-Gutierrez, D., et al. (2010) Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, 17, 763-773.