Result summary


Detailed summary for UBP10:

UBP10


Systematic name:
YNL186W
Alias:
DOT4
Description:
Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis; stabilizes Rpa190p, the largest subunit of RNAP I, by mediating its deubiquitination; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; localized to the nucleolus; human USP36 is a functional analog of Ubp10p
Related info:
The loss of UBP10, which codes for a deubiquitinating enzyme, leads to premature cell death that can be efficiently rescued by the deletion of YCA1

References


  • Bettiga, M., et al. (2004) Involvement of the yeast metacaspase Yca1 in ubp10Delta-programmed cell death, FEMS Yeast Res, 5, 141-147.
  • Mazzoni, C. and Falcone, C. (2008) Caspase-dependent apoptosis in yeast, Biochim Biophys Acta, 1783, 1320-1327.

Cross references


SGD:
UniProt:
InterPro:
Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394)
Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (IPR018200)
PSICQUIC View:
Gene Expression Atlas: