Result summary


Detailed summary for LSM1:

LSM1


Systematic name:
YJL124C
Description:
Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
Related info:
The truncated form of LSM4, leads to an accumulation of mRNAs and the phenotypic markers of apoptosis. Other mutations in the yeast mRNA-decapping pathway, such as those in the LSM1, LSM6, DCP1 and DCP2 genes, show increased mRNA stability and undergo apoptosis

References


  • Mazzoni, C., et al. (2003) A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast, Mol Biol Cell, 14, 721-729.
  • Mazzoni, C., et al. (2005) Yeast caspase 1 links messenger RNA stability to apoptosis in yeast, EMBO Rep, 6, 1076-1081.

Cross references


SGD:
UniProt:
InterPro:
Ribonucleoprotein LSM domain (IPR001163)
Ribonucleoprotein LSM domain, eukaryotic/archaea-type (IPR006649)
Like-Sm (LSM) domain (IPR010920)
PSICQUIC View:
Gene Expression Atlas: