Result summary


Detailed summary for DCP1:

DCP1


Systematic name:
YOL149W
Description:
Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
Related info:
The truncated form of LSM4, leads to an accumulation of mRNAs and the phenotypic markers of apoptosis. Other mutations in the yeast mRNA-decapping pathway, such as those in the LSM1, LSM6, DCP1 and DCP2 genes, show increased mRNA stability and undergo apoptosis

References


  • Mazzoni, C., et al. (2003) A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast, Mol Biol Cell, 14, 721-729.
  • Mazzoni, C., et al. (2005) Yeast caspase 1 links messenger RNA stability to apoptosis in yeast, EMBO Rep, 6, 1076-1081.

Cross references


SGD:
UniProt:
InterPro:
Dcp1-like decapping (IPR010334)
PSICQUIC View:
Gene Expression Atlas: