Result summary


Detailed summary for CAF4:

CAF4


Systematic name:
YKR036C
Description:
WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication
Related info:
The long-term survival function of Fis1 that is compensated by WHI2 mutation appears to be independent of fission factor Dnm1/Drp1 and its adaptor Mdv1, but might be mediated through a second adaptor Caf4, as WHI2 is also mutated in a Caf4 knockout

References


  • Zhang, Y. and Chan, D.C. (2007) Structural basis for recruitment of mitochondrial fission complexes by Fis1, Proc Natl Acad Sci U S A, 104, 18526-18530.
  • Cheng, W.C., et al. (2008) Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects, Cell Death Differ, 15, 1838-1846.

Cross references


SGD:
UniProt:
InterPro:
WD40 repeat (IPR001680)
WD40/YVTN repeat-like-containing domain (IPR015943)
WD40-repeat-containing domain (IPR017986)
WD40 repeat, conserved site (IPR019775)
G-protein beta WD-40 repeat (IPR020472)
PSICQUIC View:
Gene Expression Atlas: