Detailed summary for CAF4:
WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication
The long-term survival function of Fis1 that is compensated by WHI2 mutation appears to be independent of fission factor Dnm1/Drp1 and its adaptor Mdv1, but might be mediated through a second adaptor Caf4, as WHI2 is also mutated in a Caf4 knockout
- Zhang, Y. and Chan, D.C. (2007) Structural basis for recruitment of mitochondrial fission complexes by Fis1, Proc Natl Acad Sci U S A, 104, 18526-18530.
- Cheng, W.C., et al. (2008) Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects, Cell Death Differ, 15, 1838-1846.