Result summary

Detailed summary for WHI2:


Systematic name:
Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
Related info:
The long-term survival function of Fis1 that is compensated by WHI2 mutation appears to be independent of fission factor Dnm1/Drp1 and its adaptor Mdv1, but might be mediated through a second adaptor Caf4, as WHI2 is also mutated in a Caf4 knockout

Pathway information

  • location
    • cytoplasm
  • process
    • ROS production


  • Cheng, W.C., et al. (2008) Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects, Cell Death Differ, 15, 1838-1846.
  • Leadsham, J.E., et al. (2009) Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast, J Cell Sci, 122, 706-715.
  • Carmona-Gutierrez, D., et al. (2010) Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, 17, 763-773.

Cross references

Gene Expression Atlas: