Result summary


Detailed summary for MCA1:

MCA1


Systematic name:
YOR197W
Alias:
YCA1
Description:
Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization; Also known as: [MCA]

References


  • Herker, E., et al. (2004) Chronological aging leads to apoptosis in yeast, J Cell Biol, 164, 501-507.
  • Mazzoni, C., et al. (2005) Yeast caspase 1 links messenger RNA stability to apoptosis in yeast, EMBO Rep, 6, 1076-1081.
  • Frohlich, K.U., Fussi, H. and Ruckenstuhl, C. (2007) Yeast apoptosis--from genes to pathways, Semin Cancer Biol, 17, 112-121.
  • Mazzoni, C. and Falcone, C. (2008) Caspase-dependent apoptosis in yeast, Biochim Biophys Acta, 1783, 1320-1327.
  • Madeo, F., et al. (2009) Caspase-dependent and caspase-independent cell death pathways in yeast, Biochem Biophys Res Commun, 382, 227-231.
  • Guaragnella, N., et al. (2010) Yeast acetic acid-induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1, FEBS Lett, 584, 224-228.
  • Carmona-Gutierrez, D., et al. (2010) Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, 17, 763-773.

Cross references


SGD:
UniProt:
InterPro:
Peptidase C14, caspase catalytic (IPR011600)
PSICQUIC View:
Gene Expression Atlas: