Detailed summary for MCA1:
Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization; Also known as: [MCA]
- caspase dependent
- molecular function
- cellular component
- biological process
- Herker, E., et al. (2004) Chronological aging leads to apoptosis in yeast, J Cell Biol, 164, 501-507.
- Mazzoni, C., et al. (2005) Yeast caspase 1 links messenger RNA stability to apoptosis in yeast, EMBO Rep, 6, 1076-1081.
- Frohlich, K.U., Fussi, H. and Ruckenstuhl, C. (2007) Yeast apoptosis--from genes to pathways, Semin Cancer Biol, 17, 112-121.
- Mazzoni, C. and Falcone, C. (2008) Caspase-dependent apoptosis in yeast, Biochim Biophys Acta, 1783, 1320-1327.
- Madeo, F., et al. (2009) Caspase-dependent and caspase-independent cell death pathways in yeast, Biochem Biophys Res Commun, 382, 227-231.
- Guaragnella, N., et al. (2010) Yeast acetic acid-induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1, FEBS Lett, 584, 224-228.
- Carmona-Gutierrez, D., et al. (2010) Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, 17, 763-773.