Result summary
Detailed summary for AIM14:
AIM14
Systematic name:
YGL160W
Alias:
YNO1
Description:
NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p
Related info:
NADPH oxidase (NOX enzyme)
Pathway information
- location
- er
- process
- caspase dependent
- ROS production
Gene ontology
- molecular function
- cellular component
- biological process
References
- Rinnerthaler, M., et al. (2012) Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast, Proc Natl Acad Sci U S A, 109, 8658-8663.
Cross references
SGD:
UniProt:
InterPro:
FAD-binding 8 (IPR013112)
Ferric reductase, NAD binding (IPR013121)
Ferric reductase transmembrane component-like domain (IPR013130)
Ferric reductase, NAD binding (IPR013121)
Ferric reductase transmembrane component-like domain (IPR013130)
PSICQUIC View:
Gene Expression Atlas:
