Detailed summary for BXI1:
Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
- mitochondrial membrane permeabilization
- cellular component
- molecular function
- biological process
- Buttner, S., et al. (2011) A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis, Embo J, 30, 2779-2792.
- Cebulski, J., et al. (2011) Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae, PLoS One, 6, e20882.