Result summary


Detailed summary for BXI1:

BXI1


Systematic name:
YNL305C
Alias:
YBH3
Description:
Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
Related info:
BaX Inhibitor

Pathway information


  • location
    • mitochondria
    • er
  • process
    • anti-apoptosis
    • mitochondrial membrane permeabilization

References


  • Buttner, S., et al. (2011) A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis, Embo J, 30, 2779-2792.
  • Cebulski, J., et al. (2011) Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae, PLoS One, 6, e20882.

Cross references


SGD:
UniProt:
InterPro:
Bax inhibitor 1-related (IPR006214)
PSICQUIC View:
Gene Expression Atlas: