Result summary


Detailed summary for ESP1:

ESP1


Systematic name:
YGR098C
Description:
Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress
Related info:
When apoptosis is induced, Esp1 is released from the anaphase inhibitor Pds1

References


  • Yang, H., Ren, Q. and Zhang, Z. (2008) Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast, Mol Biol Cell, 19, 2127-2134.
  • Madeo, F., et al. (2009) Caspase-dependent and caspase-independent cell death pathways in yeast, Biochem Biophys Res Commun, 382, 227-231.

Cross references


SGD:
UniProt:
InterPro:
Peptidase C50, separase (IPR005314)
PSICQUIC View:
Gene Expression Atlas: