Result summary


Detailed summary for CDC6:

CDC6


Systematic name:
YJL194W
Description:
Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
Related info:
Cdc6p, a component of the pre-replicative complex required for the initiation of eukaryotic DNA replication, is rapidly degraded in a proteasome-dependent way in cells undergoing apoptosis induced by the DNA-damaging drug adozelesin

References


  • Blanchard, F., et al. (2002) Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast, Mol Biol Cell, 13, 1536-1549.
  • Mazzoni, C. and Falcone, C. (2008) Caspase-dependent apoptosis in yeast, Biochim Biophys Acta, 1783, 1320-1327.

Cross references


SGD:
UniProt:
InterPro:
AAA+ ATPase domain (IPR003593)
Winged helix-turn-helix DNA-binding domain (IPR011991)
Cell division protein Cdc6/18 (IPR016314 )
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
PSICQUIC View:
Gene Expression Atlas: