Result summary


Detailed summary for CDC48:

CDC48


Systematic name:
YDL126C
Description:
AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
Related info:
Yeast apoptosis was first described in cells carrying a mutation in the AAA-ATPase CDC48 gene

References


  • Jarosch, E., et al. (2002) Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48, Nat Cell Biol, 4, 134-139.
  • Mazzoni, C. and Falcone, C. (2008) Caspase-dependent apoptosis in yeast, Biochim Biophys Acta, 1783, 1320-1327.
  • Carmona-Gutierrez, D., et al. (2010) Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, 17, 763-773.

Cross references


SGD:
UniProt:
InterPro:
CDC48, N-terminal subdomain (IPR003338)
AAA+ ATPase domain (IPR003593)
ATPase, AAA-type, core (IPR003959)
ATPase, AAA-type, conserved site (IPR003960)
CDC48, domain 2 (IPR004201)
ATPase, AAA-type, CDC48 (IPR005938)
Aspartate decarboxylase-like domain (IPR009010)
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
PSICQUIC View:
Gene Expression Atlas: