Detailed summary for IZH2:
Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
A protein, involved in osmotin-induced apoptosis
- ROS production
- molecular function
- cellular component
- biological process
- Narasimhan, M.L., et al. (2005) Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor, Mol Cell, 17, 171-180.
- Gourlay, C.W., Du, W. and Ayscough, K.R. (2006) Apoptosis in yeast--mechanisms and benefits to a unicellular organism, Mol Microbiol, 62, 1515-1521.
- Carmona-Gutierrez, D., et al. (2010) Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, 17, 763-773.