Result summary


Detailed summary for HOS3:

HOS3


Systematic name:
YPL116W
Description:
Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
Related info:
Upon exposure to an apoptotic stimulus, the histone deacetylase Hos3p deacetylates K11 and allows Ste20p to phosphorylate S10, required for apoptotic cell death

References


  • Carmona-Gutierrez, D. and Madeo, F. (2006) Yeast unravels epigenetic apoptosis control: deadly chat within a histone tail, Mol Cell, 24, 167-169.
  • Ahn, S.H., et al. (2006) Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10, Mol Cell, 24, 211-220.

Cross references


SGD:
UniProt:
InterPro:
Histone deacetylase superfamily (IPR000286)
Histone deacetylase domain (IPR023801)
PSICQUIC View:
Gene Expression Atlas: