Result summary


Detailed summary for SIR2:

SIR2


Systematic name:
YDL042C
Alias:
MAR1
Description:
Conserved NAD+ dependent histone deacetylase of the Sirtuin family; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication; functions as a regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy
Related info:
The yeast GAPDH paralogue Tdh3 interacts genetically with Sir2

References


  • Sun, Q., et al. (2007) Valproate induces apoptosis by inducing accumulation of neutral lipids which was prevented by disruption of the SIR2 gene in Saccharomyces cerevisiae, FEBS Lett, 581, 3991-3995.
  • Ralser, M., Zeidler, U. and Lehrach, H. (2009) Interfering with glycolysis causes Sir2-dependent hyper-recombination of Saccharomyces cerevisiae plasmids, PLoS One, 4, e5376.

Cross references


SGD:
UniProt:
InterPro:
Sirtuin family (IPR003000)
Sirtuin family, catalytic core domain (IPR026590)
Sirtuin family, catalytic core small domain (IPR026591)
PSICQUIC View:
Gene Expression Atlas: