Result summary


Detailed summary for LSM4:

LSM4


Systematic name:
YER112W
Alias:
SDB23, USS1
Description:
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
Related info:
The truncated form of LSM4, leads to an accumulation of mRNAs and the phenotypic markers of apoptosis. Other mutations in the yeast mRNA-decapping pathway, such as those in the LSM1, LSM6, DCP1 and DCP2 genes, show increased mRNA stability and undergo apoptosis

References


  • Mazzoni, C., et al. (2003) A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast, Mol Biol Cell, 14, 721-729.
  • Mazzoni, C., et al. (2005) Yeast caspase 1 links messenger RNA stability to apoptosis in yeast, EMBO Rep, 6, 1076-1081.

Cross references


SGD:
UniProt:
InterPro:
Ribonucleoprotein LSM domain (IPR001163)
Ribonucleoprotein LSM domain, eukaryotic/archaea-type (IPR006649)
Like-Sm (LSM) domain (IPR010920)
U6 snRNA-associated Sm-like protein LSm4/Small nuclear ribonucleoprotein Sm D1/D3 (IPR027141)
PSICQUIC View:
Gene Expression Atlas: