Result summary
Detailed summary for DCP2:
DCP2
Systematic name:
YNL118C
Description:
Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
Related info:
The truncated form of LSM4, leads to an accumulation of mRNAs and the phenotypic markers of apoptosis. Other mutations in the yeast mRNA-decapping pathway, such as those in the LSM1, LSM6, DCP1 and DCP2 genes, show increased mRNA stability and undergo apoptosis
Pathway information
- location
- cytoplasm
- process
- caspase dependent
- mRNA stability
Gene ontology
- biological process
- cellular component
- molecular function
References
- Mazzoni, C., et al. (2003) A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast, Mol Biol Cell, 14, 721-729.
- Mazzoni, C., et al. (2005) Yeast caspase 1 links messenger RNA stability to apoptosis in yeast, EMBO Rep, 6, 1076-1081.
Cross references
SGD:
UniProt:
InterPro:
NUDIX hydrolase domain (IPR000086)
mRNA decapping protein 2, Box A (IPR007722)
NUDIX hydrolase domain-like (IPR015797)
NUDIX hydrolase, conserved site (IPR020084)
mRNA decapping protein 2, Box A (IPR007722)
NUDIX hydrolase domain-like (IPR015797)
NUDIX hydrolase, conserved site (IPR020084)
PSICQUIC View:
Gene Expression Atlas:
