Result summary


Detailed summary for PDS1:

PDS1


Systematic name:
YDR113C
Description:
Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
Related info:
When apoptosis is induced, Esp1 is released from the anaphase inhibitor Pds1

Pathway information


  • location
    • nucleus
  • process
    • caspase dependent
    • anti-apoptosis

References


  • Yang, H., Ren, Q. and Zhang, Z. (2008) Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast, Mol Biol Cell, 19, 2127-2134.
  • Madeo, F., et al. (2009) Caspase-dependent and caspase-independent cell death pathways in yeast, Biochem Biophys Res Commun, 382, 227-231.

Cross references


SGD:
UniProt:
InterPro:
Securin sister-chromatid separation inhibitor (IPR006940)
PSICQUIC View:
Gene Expression Atlas: