Detailed summary for STE20:
Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
Upon exposure to an apoptotic stimulus, the histone deacetylase Hos3p deacetylates K11 and allows Ste20p to phosphorylate S10, required for apoptotic cell death
- caspase independent
- histone modification
- pheromone induced cell death
- biological process
- vacuole inheritance
- activation of MAPKKK activity
- cellular bud site selection
- pheromone-dependent signal transduction involved in conjugation with cellular fusion
- signal transduction involved in filamentous growth
- invasive growth in response to glucose limitation
- protein phosphorylation
- cell cycle
- regulation of exit from mitosis
- pseudohyphal growth
- osmosensory signaling pathway via Sho1 osmosensor
- negative regulation of gene expression
- response to pheromone
- stress granule assembly
- cellular response to heat
- sterol import
- positive regulation of apoptotic process
- cellular component
- molecular function
- Severin, F.F. and Hyman, A.A. (2002) Pheromone induces programmed cell death in S. cerevisiae, Curr Biol, 12, R233-235.
- Ahn, S.H., et al. (2005) Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae, Cell, 120, 25-36.
- Ahn, S.H., et al. (2005) H2B (Ser10) phosphorylation is induced during apoptosis and meiosis in S. cerevisiae, Cell Cycle, 4, 780-783.
- Carmona-Gutierrez, D. and Madeo, F. (2006) Yeast unravels epigenetic apoptosis control: deadly chat within a histone tail, Mol Cell, 24, 167-169.
- Ahn, S.H., et al. (2006) Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10, Mol Cell, 24, 211-220.
- Frohlich, K.U., Fussi, H. and Ruckenstuhl, C. (2007) Yeast apoptosis--from genes to pathways, Semin Cancer Biol, 17, 112-121.
- Madeo, F., et al. (2009) Caspase-dependent and caspase-independent cell death pathways in yeast, Biochem Biophys Res Commun, 382, 227-231.
- Carmona-Gutierrez, D., et al. (2010) Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, 17, 763-773.
Gene Expression Atlas: