Detailed summary for NDI1:
NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID
- ROS production
- biological process
- cellular component
- molecular function
- Li, W., et al. (2006) Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging, Mol Biol Cell, 17, 1802-1811.
- Frohlich, K.U., Fussi, H. and Ruckenstuhl, C. (2007) Yeast apoptosis--from genes to pathways, Semin Cancer Biol, 17, 112-121.
- Rockenfeller, P. and Madeo, F. (2008) Apoptotic death of ageing yeast, Exp Gerontol, 43, 876-881.
- Carmona-Gutierrez, D., et al. (2010) Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, 17, 763-773.
Gene Expression Atlas: